Thermoresponsive Polymer Colloids for Drug Delivery and Cancer Therapy
Identifieur interne : 002510 ( Main/Exploration ); précédent : 002509; suivant : 002511Thermoresponsive Polymer Colloids for Drug Delivery and Cancer Therapy
Auteurs : Samer R. Abulateefeh [Royaume-Uni, Jordanie] ; Sebastian G. Spain [Royaume-Uni] ; Jonathan W. Aylott [Royaume-Uni] ; Weng C. Chan [Royaume-Uni] ; Martin C. Garnett [Royaume-Uni] ; Cameron Alexander [Royaume-Uni]Source :
- Macromolecular Bioscience [ 1616-5187 ] ; 2011-12-08.
English descriptors
- Teeft :
- Abulateefeh, Alexander figure, Aunps, Aylott, Biosci, Cancer therapy, Cell uptake, Chan, Chem, Cheng, Chilkoti, Colloid, Colloid interface, Colloidal, Colloids surf, Copolymer, Dewhirst, Drug delivery, Drug release, Garnett, Gmbh, Healthy tissue, Higher drug release, Hydrophobic, Kgaa, Langmuir, Lcst, Lipid, Lipid bilayers, Liposome, Macromol, Magn, Magnetic heating, Mater, Micelle, Mnps, Normal tissue, Okano, Phase separation, Phase transition, Polymer, Royal society, Schmidt, Thermal transition, Thermoresponsive, Thermoresponsive aunps, Thermoresponsive block, Thermoresponsive colloids, Thermoresponsive materials, Thermoresponsive polymers, Thermoresponsive shell, Tumour, Tumour vasculature, Utilised, Verlag, Verlag gmbh, Wang, Weinheim, Weinheim thermoresponsive polymer colloids, Zhang.
Abstract
Many difficulties in treating cancer arise from the problems in directing highly cytotoxic agents to the deseased tissues, cells and intracellular compartments. Many drug delivery systems have been devised to address this problem, including those that show a change in properties in response to a temperature stimulus. In particular, colloidal materials based on thermoresponsive polymers offer a means to transport drugs selectively into tumour tissues that are hyperthermic, either intrinsically or through the application of clinical procedures such as localised heating. In this paper, the key attributes of thermoresponsive polymer colloids are considered, a number of important recent examples are discussed and the possible future developments of these materials are evaluated.
Thermoresponsive polymers have a large number of potential uses in medicine. In this paper, the possible applications of these materials for delivery and release of cytotoxic agents for cancer therapy are explored. The state of the art for these materials is reviewed and emerging trends for the future are outlined.
Url:
DOI: 10.1002/mabi.201100252
Affiliations:
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Many drug delivery systems have been devised to address this problem, including those that show a change in properties in response to a temperature stimulus. In particular, colloidal materials based on thermoresponsive polymers offer a means to transport drugs selectively into tumour tissues that are hyperthermic, either intrinsically or through the application of clinical procedures such as localised heating. In this paper, the key attributes of thermoresponsive polymer colloids are considered, a number of important recent examples are discussed and the possible future developments of these materials are evaluated.</div><div type="abstract" xml:lang="en">Thermoresponsive polymers have a large number of potential uses in medicine. In this paper, the possible applications of these materials for delivery and release of cytotoxic agents for cancer therapy are explored. The state of the art for these materials is reviewed and emerging trends for the future are outlined.</div></front></TEI><affiliations><list><country><li>Jordanie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Nottinghamshire</li></region><settlement><li>Nottingham</li></settlement><orgName><li>Université de Nottingham</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Abulateefeh, Samer R" sort="Abulateefeh, Samer R" uniqKey="Abulateefeh S" first="Samer R." last="Abulateefeh">Samer R. Abulateefeh</name></region><name sortKey="Alexander, Cameron" sort="Alexander, Cameron" uniqKey="Alexander C" first="Cameron" last="Alexander">Cameron Alexander</name><name sortKey="Alexander, Cameron" sort="Alexander, Cameron" uniqKey="Alexander C" first="Cameron" last="Alexander">Cameron Alexander</name><name sortKey="Alexander, Cameron" sort="Alexander, Cameron" uniqKey="Alexander C" first="Cameron" last="Alexander">Cameron Alexander</name><name sortKey="Aylott, Jonathan W" sort="Aylott, Jonathan W" uniqKey="Aylott J" first="Jonathan W." last="Aylott">Jonathan W. Aylott</name><name sortKey="Chan, Weng C" sort="Chan, Weng C" uniqKey="Chan W" first="Weng C." last="Chan">Weng C. Chan</name><name sortKey="Garnett, Martin C" sort="Garnett, Martin C" uniqKey="Garnett M" first="Martin C." last="Garnett">Martin C. Garnett</name><name sortKey="Spain, Sebastian G" sort="Spain, Sebastian G" uniqKey="Spain S" first="Sebastian G." last="Spain">Sebastian G. Spain</name></country><country name="Jordanie"><noRegion><name sortKey="Abulateefeh, Samer R" sort="Abulateefeh, Samer R" uniqKey="Abulateefeh S" first="Samer R." last="Abulateefeh">Samer R. Abulateefeh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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